John Libbey Eurotext

Annales de Biologie Clinique

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Histiocytes en bleu de mer observés dans le myélogramme d’un patient atteint d’une maladie de Niemann-Pick de type C2 Volume 78, numéro 4, Juillet-Août 2020

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  • Figure 1

Tableaux

Auteurs
1 Laboratoire d’hématologie, Groupe Hospitalier de la région Mulhouse Sud Alsace, Mulhouse, France
2 Service de médecine interne, Groupe Hospitalier de la région Mulhouse Sud Alsace, Mulhouse, France
* Correspondence

A 45-year-old woman presented with a one-year history of progressive cognitive impairment, weight loss and walking difficulties. Clinical examination showed hepatomegaly without splenomegaly. Cerebral magnetic resonance imaging revealed frontal and temporal atrophy. Mild anemia led to analyze the bone marrow aspiration which revealed the presence of sea-blue histiocytes (SBH) and several macrophages (figure 1). This cytological feature associated with neurological manifestations suggested the search [...]