John Libbey Eurotext

Epileptic Disorders

The Educational Journal of the International League Against Epilepsy

Seizure semiology of anti-LGI1 antibody encephalitis Volume 19, numéro 4, December 2017


  • Seizure semiology of anti-LGI1 antibody encephalitis
Department of Neurology, University of Michigan, Michigan, USA
* Correspondence: Nicholas J. Beimer Department of Neurology, University of Michigan, F2593 UH South/5223, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-7310, USA
  • Mots-clés : LGI1, encephalitis, faciobrachial, dystonic, ictal speech, temporal
  • DOI : 10.1684/epd.2017.0936
  • Page(s) : 461-4
  • Année de parution : 2017

Limbic encephalitis associated with anti-LGI1 antibody (LGI1 encephalitis) presents with a variety of features, the most prominent of which include seizures and progressive disturbance of memory and behaviour. Although varied in semiology, recognition of the pattern of seizures in LGI1 encephalitis is important, as early diagnosis and definitive treatment may prevent subsequent development of cognitive impairment. We present a patient with LGI1 encephalitis and “faciobrachial dystonic seizures-plus”, which began as classic faciobrachial dystonic seizures and progressed to focal seizures with impaired awareness, dacrystic/gelastic-like outbursts, ictal speech, manual automatisms, and autonomic signs (tachycardia). Recognition of the broad range of seizure types associated with LGI1 encephalitis is crucial for early diagnosis and definitive treatment. [Published with video sequence on]