John Libbey Eurotext

Epileptic Disorders

The Educational Journal of the International League Against Epilepsy

Amoxicillin, a potential epileptogenic drug Volume 18, numéro 4, December 2016

Illustrations

  • Figure 1
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Auteurs
Epilepsy Center of Centro Hospitalar e Universitário de Coimbra, Portugal
* Correspondence: João Raposo Centro Hospitalar e Universitário de Coimbra (Epilepsy Center), Praceta Prof. Mota Pinto, 3000-075 Coimbra, Portugal
  • Mots-clés : amoxicillin, beta-lactam, epileptogenic drug
  • DOI : 10.1684/epd.2016.0875
  • Page(s) : 454-7
  • Année de parution : 2016

Beta-lactams are known to cause a wide spectrum of neurotoxic manifestations including epileptic seizures. The neurotoxicity of penicillin was first reported in 1945 by Johnson and Walker and is believed to exert an inhibitory effect on gamma-aminobutyric acid transmission of cortical pyramidal cells, due to its beta-lactam ring structure. Epileptogenicity is also a feature of the semisynthetic beta-lactams including aminopenicillins. In this report, we present a patient with a recurrent history of discrete body twitching/jerks of epileptic nature in the context of amoxicillin exposure. The EEG revealed intermittent generalized short bursts of beta-frequency polyspikes. This electro-clinical picture was reversed by amoxicillin discontinuation.