John Libbey Eurotext

Epileptic Disorders

The Educational Journal of the

7 tesla T2*-weighted MRI as a tool to improve detection of focal cortical dysplasia Volume 18, numéro 3, September 2016


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1 Department of Neurology and Neurosurgery, Brain Center Rudolg Magnus, University Medical Center Utrecht
2 Department of Radiology, University Medical Center Utrecht
3 Department of Pathology, University Medical Center Utrecht
4 Academic Medical Center, Department of Pathology, Amsterdam, The Netherlands
* Correspondence: Tim J. Veersema Universitair Medisch Centrum Utrecht, Internal post number G03.232, PO Box 85500, 3508 GA Utrecht, The Netherlands
  • Mots-clés : epilepsy, FCD, cortical localization, susceptibility weighted, ultra-high field, magnetic resonance imaging
  • DOI : 10.1684/epd.2016.0838
  • Page(s) : 315-23
  • Année de parution : 2016

Focal cortical dysplasia is one of the most common underlying pathologies in patients who undergo surgery for refractory epilepsy. Absence of a MRI-visible lesion necessitates additional diagnostic tests and is a predictor of poor surgical outcome. We describe a series of six patients with refractory epilepsy due to histopathologically-confirmed focal cortical dysplasia, for whom pre-surgical 7 tesla T2*-weighted MRI was acquired. In four of six patients, T2* sequences showed areas of marked superficial hypointensity, co-localizing with the epileptogenic lesion. 7 tesla T2* hypointensities overlying focal cortical dysplasia may represent leptomeningeal venous vascular abnormalities associated with the underlying dysplastic cortex. Adding T2* sequences to the MRI protocol may aid in the detection of focal cortical dysplasias.