John Libbey Eurotext

European Cytokine Network


Skin innate immune response to flaviviral infection Volume 28, numéro 2, June 2017


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1 Laboratoire inflammation tissus épithéliaux et cytokines EA 4331, université de Poitiers, Poitiers, France
2 Laboratoire de virologie et mycobactériologie, CHU de Poitiers, Poitiers, France
* Correspondence: Charles Bodet, LITEC EA 4331, université de Poitiers, B36, 1, rue Georges-Bonnet, TSA 51106, 86073 Poitiers cedex 9, France.
  • Mots-clés : flavivirus, inflammation, signalling pathway, RIG-I, TLR3, MDA5
  • DOI : 10.1684/ecn.2017.0394
  • Page(s) : 41-51
  • Année de parution : 2017

Skin is a complex organ and the largest interface of the human body exposed to numerous stress and pathogens. Skin is composed of different cell types that together perform essential functions such as pathogen sensing, barrier maintenance and immunity, at once providing the first line of defense against microbial infections and ensuring skin homeostasis. Being inoculated directly through the epidermis and the dermis during a vector blood meal, emerging Dengue, Zika and West Nile mosquito-borne viruses lead to the initiation of the innate immune response in resident skin cells and to the activation of dendritic cells, which migrate to the draining lymph node to elicit an adaptive response. This literature review aims to describe the inflammatory response and the innate immune signalization pathways involved in human skin cells during Dengue, Zika and West Nile virus infections.