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 Printable version |
Introduction to structural bioinformatics; applications to blood coagulation factor V and factor VIII |
Hématologie. Volume 7, Number 4, 287-96, Juillet - Août 2001, Revues
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 Résumé
Article gratuit
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Author(s) : Bruno O. Villoutreix, Gerry A. F. Nicolaes, Martine Aiach |
Summary : Bioinformatics enables prediction of protein structures and functions and contributes to the design of new therapeutic compounds. These computer methods are also used to study DNA/RNA, polysaccharides, phospholipids or other small molecules. These theoretical approaches guide the design of experiments aiming to establish correlations between structure and activity; while assisting the analysis of experimental results. Blood coagulation involves formation of several macromolecular complexes. Proper functioning of this biological system depends on numerous protein/protein and protein/membrane interactions that are not well understood at present. We here describe some of the tools used in structural bioinformatics and show how to apply these concepts to coagulation factor V and factor VIII. |
Keywords : factor V, factor VIII, structural bioinformatics, molecular modeling. |
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