JLE

European Journal of Dermatology

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Discoid lupus erythematosus (DLE)-like lesion induced by uracil-tegafur (UFT) Volume 11, numéro 1, January - February 2001

Auteurs
Department of Dermatology, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-0012 Japan.
  • Page(s) : 54-7
  • Année de parution : 2001

It is well known in Japan that fluorouracil agents induce discoid lupus erythematosus (DLE)-like eruptions. The frequency of DLE-like eruption is about 10% among all cases of drug eruptions induced by fluorouracil agents, based on the statistical report of Fukuda [1]. UFT, a combination of uracil and tegafur, is a second generation anticancer agent. Tegafur is an antimetabolite which is slowly converted to 5-fluorouracil (5-FU) in vivo. [...]