John Libbey Eurotext

Magnesium Research


The tissue-specific “ferromagnetic attack” on hyperactivation of ATP synthesis by magnesium-25 in mitochondria Volume 25, numéro 4, December 2012

Department of Life Sciences, Moscow Region Pedagogical University, Orekhovo-Zouyevo, Moscow Provivce, Russia, Department of Pharmacology, School of Pharmacy, I. M. Sechenov Moscow State Medical University, Moscow, Russia, Department of Medicinal Nanobiotechnologies, N. I. Pirogov Russian National Research Medical University and Russian Academy of Sciences Institute for Chemical Physics, Moscow, Russia, Department of Pharmacology, MARA University of Technology School of Medicine, Selangor, Malaysia
  • Mots-clés : magnesium-25, ferromagnetism, mitochondria, ATP
  • DOI : 10.1684/mrh.2012.0328
  • Page(s) : 177-81
  • Année de parution : 2012

A 25Mg 2+-operated hyper -activation of ATP synthesis has been investigated in mitochondria (Mt) isolated from iron-rich and iron-poor rat tissues: spleen, liver, skeletal muscle, myocardium, kidneys, brain. Both magnetic ( 25Mg) and non-magnetic ( 24Mg) magnesium isotopes were separately administered to estimate the degree of the ATP production related to the magnetic isotope effect (MIE) of 25Mg 2+ as a function of the amount of Mt-endogenous iron ions. A strong but negative ( r = -0.88) correlation between the 25Mg-MIE degree and the Mt[Fe 2+] values was found. The physical and biophysical mechanisms behind these phenomena, as well as the possible impact of these data on further biochemical and pharmacological studies involving 25Mg-promoted nuclear spin selectivity in mitochondrial function, are under discussion.