John Libbey Eurotext

Magnesium Research


Serum magnesium and calcium levels in infertile women during a cycle of reproductive assistance Volume 30, numéro 2, April-May-June 2017


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1 Unit of Obstetrics, Gynecology, Department of Biomedical, Clinical Sciences, ASST Fatebenefratelli Sacco, Hospital “L. Sacco” via GB Grassi 74, Milan, Italy
2 Centre for Fetal Research Giorgio Pardi
3 Departments of Biomedical and Clinical Sciences Luigi Sacco, Italy
* Correspondence: Elena Grossi. University of Milan, ASST Fatebenefratelli – Sacco Via G. B. Grassi, 74, 20157 Milan, Italy
  • Mots-clés : infertility, intrauterine insemination, in vitro fertilization, estrogen, total serum magnesium level, total serum calcium level
  • DOI : 10.1684/mrh.2017.0421
  • Page(s) : 35-41
  • Année de parution : 2017

Magnesium (Mg) and calcium (Ca) are essential cations for women's preconception health. It is well known that, in blood, the concentration of ionized form of these two cations is temporally altered during menstrual cycle, suggesting a correlation between sex steroid hormones and serum calcium and magnesium levels. Evidence from literature suggests that in assisted reproductive technology increasing estrogens during ovarian hyperstimulation may also modulate serum magnesium and calcium levels. Therefore, we first examined total serum magnesium and calcium levels during follicular phase in a large population of infertile patients who underwent intrauterine insemination (IUI). The results were compared to a group of fertile women. Successively, we studied the total serum magnesium and calcium concentrations in infertile patients before and after ovarian hyperstimulation for in vitro fertilization (IVF). Results highlight that total serum concentration of magnesium and calcium does not seem altered in infertile women. During stimulation with gonadotropins, the values of the two cations do not change significantly in ovarian-stimulated women. However, we found a downward trend in the total magnesium and calcium levels in relation to the rising estrogens.