Magnesium Research
MENUMagnesium and other bivalent cations influence upon sodium montelukast effect in experimental-induced thermoalgesia Volume 21, numéro 1, march 2008
Illustrations
- Mots-clés : magnesium, zinc, copper, montelukast, leukotrienes, thermoalgesia, rat
- DOI : 10.1684/mrh.2008.0125
- Page(s) : 38-42
- Année de parution : 2008
We tested the influence of magnesium, zinc and copper upon the montelukast (MK, antagonist of cysteinyl leukotriene receptor type 1) effect in experimentally-induced thermoalgesia. We worked on 5 groups of 10 adults, each Wistar rats, that received: group I-control; group II: MK (10 mg/kg) unique administration; group III: MgCl2 (1 mM/kg/day) i.p., 3 days and MK (10 mg/kg) unique administration on the 3rd day; group IV: ZnCl2 (0.1 mM/kg/day), i.p., 3 days and MK (10 mg/kg) unique administration on the 3 rd day; group V: copper acetate (0.05 mM/kg/day), i.p., 3 days and MK (10 mg/kg) unique administration on the 3rd day. We determined the thermoalgesic sensitivity (TS) using a tail flick analgesia meter, initially, 3 days after daily cation administration and 3 hours after MK administration. Our data show that MK has a statistically significant reduction of TS vs control group (3.76 ± 1.04 s vs 1.81 ± 0.98 s, p < 0.05). Copper and magnesium administration do not significantly change the MK effect to decrease TS. The co-administration of zinc and MK statistically significantly increased the TS of the group that received only MK (2.51 ± 0.21 s vs 3.76 ± 1.04 s, p < 0.05). Animals that received only cations (in the above mentioned doses) did not significantly change TS.