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Magnesium and other bivalent cations influence upon sodium montelukast effect in experimental-induced thermoalgesia Volume 21, numéro 1, march 2008

Auteurs
Department of Pharmacology;, Department of Biophysics, University of Medicine and Pharmacy “Gr.T. Popa”, Iasi, Romania

We tested the influence of magnesium, zinc and copper upon the montelukast (MK, antagonist of cysteinyl leukotriene receptor type 1) effect in experimentally-induced thermoalgesia. We worked on 5 groups of 10 adults, each Wistar rats, that received: group I-control; group II: MK (10 mg/kg) unique administration; group III: MgCl2 (1 mM/kg/day) i.p., 3 days and MK (10 mg/kg) unique administration on the 3rd day; group IV: ZnCl2 (0.1 mM/kg/day), i.p., 3 days and MK (10 mg/kg) unique administration on the 3 rd day; group V: copper acetate (0.05 mM/kg/day), i.p., 3 days and MK (10 mg/kg) unique administration on the 3rd day. We determined the thermoalgesic sensitivity (TS) using a tail flick analgesia meter, initially, 3 days after daily cation administration and 3 hours after MK administration. Our data show that MK has a statistically significant reduction of TS vs control group (3.76 ± 1.04 s vs 1.81 ± 0.98 s, p < 0.05). Copper and magnesium administration do not significantly change the MK effect to decrease TS. The co-administration of zinc and MK statistically significantly increased the TS of the group that received only MK (2.51 ± 0.21 s vs 3.76 ± 1.04 s, p < 0.05). Animals that received only cations (in the above mentioned doses) did not significantly change TS.