John Libbey Eurotext

Magnesium Research

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Hypomagnesemia and mortality in patients with type 2 diabetes Volume 21, numéro 3, September 2008

Auteurs
General Hospital of the Mexican Social Security Institute at Durango; Av. Normal y Predio Canoas S/N; 34067, Durango, Dgo. Mexico, Biomedical Research Unit of the Mexican Social Security Institute, Durango, Mexico, and Research Group on Diabetes and Chronic Illnesses, Durango, Mexico; Canoas 100, 34067 Durango, Dgo., Mexico
  • Mots-clés : hypomagnesemia, diabetes, critical care, mortality
  • DOI : 10.1684/mrh.2008.0140
  • Page(s) : 163-6
  • Année de parution : 2008

To evaluate if hypomagnesemia, at the time of admission in the Intensive care Unit (ICU), is associated with a higher mortality in critically ill patients with type 2 diabetes. Fourteen consecutive critically ill patients with type 2 diabetes admitted in the ICU of a teaching General Hospital serving an inner city population were enrolled in a follow-up study. Parenteral or enteral nutritional support, surgical procedures, malignancy, traumatism or physical injury, pulmonary and/or cardiovascular diseases, chronic renal failure, hepatic cirrhosis, cerebrovascular disease, and disorders of the thyroid gland, were exclusion criteria. Hypomagnesemia was defined by serum magnesium levels < 0.66 mmol/L (1.6 mg/dL). At the time of admission in the ICU, 10 (71.4%) individuals had hypomagnesemia. Mortality rates in the hypomagnesemic and normomagnesemic individuals were 80 and 25%, respectively. Serum magnesium levels were significantly lower in the subjects who died (0.51 [0.41, 0.62] mmol/L) compared with those who survived (0.85 [0.65, 1.11], mmol/L), p = 0.01. The logistic regression model adjusted by APACHE II score and hsCRP levels showed that hypomagnesemia is independently associated with mortality (OR 1.9, CI 95% 1.2-14.7). Hypomagnesemia at the time of admission in the ICU seems to be associated with high mortality in critically ill patients with type 2 diabetes.