John Libbey Eurotext

European Journal of Dermatology

Treatment and mortality rate of bullous pemphigoid in China: a hospital-based study Volume 23, numéro 1, January-February 2013

Auteurs
Department of Dermatology, The First Affiliated Hospital of China Medical University, 155 North Nanjing Street, Shenyang 110001, China
  • Mots-clés : bullous pemphigoid, cerebrovascular disease, corticosteroid, mortality, prognosis
  • DOI : 10.1684/ejd.2012.1906
  • Page(s) : 94-8
  • Année de parution : 2013

Bullous pemphigoid (BP) has been reported to be associated with significant morbidities and a considerable mortality rate. We retrospectively studied 94 patients with BP in a Chinese tertiary medical center between 2005 and 2010 to evaluate the treatment of BP and prognostic factors for the mortality of BP. Cerebrovascular diseases (42.55%) and hypertension (39.36%) were the most common pre-existing conditions. Cardiopathy, diabetes and psoriasis pre-existed in 24.47%, 22.34% and 5.32%, respectively. Eighty of all 94 patients were treated by systemic corticosteroid at prednisone 0.3 mg/kg to 1.5 mg/kg daily. Patients were followed up for a minimum of 1 year or until the time of death. The mean duration of follow-up was 32 months. Kaplan–Meier analysis showed a 1-year survival probability of 76.6% (standard error 4.4%), with a 95% confidence interval (68.04%, 85.16%). Multivariate analysis revealed that increased age, bedridden condition, presence of cerebrovascular diseases at diagnosis, pre-existing cardiopathy and low serum albumin level were associated with the elevated 1-year mortality rate of BP.