European Journal of Dermatology


TNF-α inhibitor-induced paradoxical psoriasis and erythema nodosum in a patient with ankylosing spondylitis Volume 31, numéro 3, May-June 2021


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Department of Dermatology, Iwate Medical University School of Medicine, 2-1-1, Idaidori, Yahaba-cho, Iwate 028-3695, Japan

Tumour necrosis factor (TNF)-α inhibitors are widely used for the treatment of immune-mediated inflammatory diseases. However, there have been increasing reports indicating that these agents have various cutaneous side effects such as psoriasis, also known as a “paradoxical reaction” [1]. Here we report a case of paradoxical psoriasis and erythema nodosum (EN) induced by two TNF-α inhibitors, infliximab and adalimumab, used for treatment of ankylosing spondylitis (AS).The patient was a 65-year-old [...]