John Libbey Eurotext

European Journal of Dermatology

The novel drug CS-891 inhibits 5alpha-reductase activity in freshly isolated dermal papilla of human hair follicles Volume 10, numéro 8, December 2000


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The local conversion of testosterone (T) to the more potent androgen dihydrotestosterone (DHT) by 5alpha-reductase (5aR) plays a pivotal role in the development of androgenetic alopecia (AGA) and hirsutism [1-3]. There are at least two isoforms of 5aR, namely type I and II, characterized by distinct molecular, structural and biochemical properties and by different tissue localization [4, 5]. Early studies have shown that individuals lacking...