John Libbey Eurotext

European Journal of Dermatology


The novel drug CS-891 inhibits 5alpha-reductase activity in freshly isolated dermal papilla of human hair follicles Volume 10, numéro 8, December 2000

Department of Dermatology, Philipp University, Deutschhausstrasse 9, D-35033 Marburg, Germany.
  • Page(s) : 593-5
  • Année de parution : 2000

The local conversion of testosterone (T) to the more potent androgen dihydrotestosterone (DHT) by 5alpha-reductase (5aR) plays a pivotal role in the development of androgenetic alopecia (AGA) and hirsutism [1-3]. There are at least two isoforms of 5aR, namely type I and II, characterized by distinct molecular, structural and biochemical properties and by different tissue localization [4, 5]. Early studies have shown that individuals lacking [...]