Department of Dermatology, Philipp University, Deutschhausstrasse 9, D-35033 Marburg, Germany.
- Page(s) : 593-5
- Année de parution : 2000
The local conversion of testosterone (T) to the more potent androgen
dihydrotestosterone (DHT) by 5alpha-reductase (5aR) plays a pivotal role
in the development of androgenetic alopecia (AGA) and hirsutism [1-3].
There are at least two isoforms of 5aR, namely type I and II, characterized
by distinct molecular, structural and biochemical properties and by different
tissue localization [4, 5]. Early studies have shown that individuals