John Libbey Eurotext

European Journal of Dermatology


Sunlight is merely a temporary modifier of dyschromatosis symmetrica hereditaria Volume 28, numéro 2, March-April 2018


  • Figure 1
Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

Dyschromatosis symmetrica hereditaria (DSH) is an autosomal dominant skin disease caused by a heterozygous mutation in the adenosine deaminases acting on RNA 1 gene (ADAR1) [1]. DSH is characterized by a mixture of hyper- and hypo-pigmented small macules on the dorsal aspects of the extremities [2]. Bi-allelic ADAR1 mutations [3] and the heterozygous ADAR1 mutation p.Gly1007Arg [4] are also known to cause Aicardi-Goutières syndrome 6.The pathogenesis of DSH remains to be clarified. Several environmental [...]