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European Journal of Dermatology

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Stevens-Johnson syndrome-like exanthema secondary to methotrexate histologically simulating acute graft-versus-host disease Volume 10, numéro 7, October - November 2000

Auteurs
Department of Dermatology, University of Cologne, Klinik und Poliklinik für Dermatologie und Venerologie der Universität zu Köln, Joseph-Stelzmannstr. 9, 50924 Köln, Germany.
  • Page(s) : 548-50
  • Année de parution : 2000

In 1951 MTX was introduced for the therapy of severe psoriasis vulgaris. MTX is an antimetabolite which competitively inhibits dihydrofolatereductase, and thus the synthesis of purines and thymidine acid [1]. Its major effect on the cell cycle is a potentially reversible inhibition of proliferation in the late G1-phase and lethal cytotoxity in the S-phase. The antipsoriatic effect is based on its antiproliferative, anti-inflammatory and possibly [...]