John Libbey Eurotext

European Journal of Dermatology


Signaling moderation: TGF-β in exocrine gland development, maintenance, and regulation Article à paraître

Division of Developmental Biology, Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA, Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
  • Mots-clés : Exocrine gland, microenvironment, signal transduction, TGF-β signaling
  • DOI : 10.1684/ejd.2013.1979

The TGF-β superfamily is involved in embryonic development and regulation of many cellular processes. Importantly, these signaling molecules have been increasingly revealed to play a crucial role in exocrine gland maintenance and regulation. TGF-β is involved in controlling the branching morphogenesis that is common to most exocrine glands, including: mammary gland, salivary, prostate, and in sebaceous gland regulation. In this review, we explore the molecular mechanisms and uses of TGF-β in crafting the microenvironment of epithelial tissues surrounding these exocrine glands and how perturbations in the signaling pathway affect their differentiation and proper development.