European Journal of Dermatology


Serum miR-124 up-regulation as a disease marker of toxic epidermal necrolysisIncreased serum levels of miR-124 in TEN Volume 25, numéro 5, September-October 2015


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Department of Dermatology and Plastic Surgery,
Faculty of Life Sciences, Kumamoto
University, 1-1-1 Honjo, Kumamoto,
860-8556, Japan
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Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous drug adverse reactions characterized by targetoid erythema and erosion of the skin and mucous membranes. Erythema multiforme (EM) is divided into 2 types, minor EM and major EM. Major EM is considered to be a common type of drug eruption and in the same spectrum as SJS and TEN. In SJS or TEN, keratinocyte apoptosis occurs through abnormally activated cytotoxic T-cells, though detailed mechanisms remain unknown [...]