JLE

European Journal of Dermatology

MENU

Scleroderma and malignancy. Mechanisms of interrelationship Volume 12, numéro 3, May - June 2002

Auteur
Department of Dermatology, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany.
  • Page(s) : 296-300
  • Année de parution : 2002

Introduction Scleroderma (progressive systemic sclerosis) is an autoimmune disease with a usually progressive and frequently fatal course. It is characterised by widespread alterations in connective tissue, vascular lesions and immunological abnormalities. The pathogenesis remains unclear although genetic predisposition, auto-antibodies and auto-aggressive T-lymphocytes seem to be of pathogenetic relevance. A variety of associations [...]