John Libbey Eurotext

European Journal of Dermatology


Reduced IgG anti-desmocollin autoantibody titre and concomitant improvement in a patient with pemphigus vegetans Volume 28, numéro 2, March-April 2018


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1 Division of Dermatology, Department of Medicine of Sensory and Motor Organs,
Faculty of Medicine, Tottori University, Yonago, Japan
2 Department of Dermatology, Kurume University School of Medicine, Kurume, Japan
3 Kurume University Institute of Cutaneous Cell Biology, Kurume, Japan

Pemphigus vegetans (Pveg) is a rare variant of pemphigus vulgaris (PV). Pveg affects intertriginous areas, lips, and the oral mucosa, with characteristic papillomatous vegetating plaques with blisters and erosion. The main target antigen for PVeg is desmoglein (Dsg) 3 [1].In addition, IgG anti-Dsg1, IgA anti-Dsg3, and IgG anti-desmocollin (Dsc) autoantibodies have been detected in some cases [2-7]. PVeg with IgG anti-Dsc, but not anti-Dsg autoantibodies, has rarely been reported [5-7]. Moreover, [...]