Department of Dermatology,
Jacobs School of Medicine and Biomedical Sciences,
University at Buffalo,
Clinical and Translational Research Center,
875 Ellicott Street,
It is well accepted that pemphigus vulgaris (PV) is genetically linked to specific HLA class II subtypes. Environmental factors, including the role of herpes simplex virus (HSV1) in disease manifestation, have also been implicated, but in a limited number of patients and with inconsistent results.