John Libbey Eurotext

European Journal of Dermatology


Pathological score for the evaluation of allograft rejection in human hand (composite tissue) allotransplantation Volume 15, numéro 4, July-August 2005

Department of Dermatology/EA 37-32 UCBL, Ed. Herriot Hospital, Lyon, France, Department of Surgery and Transplantation, Ed. Herriot Hospital, Lyon, France, Hand Surgery & Reconstructive Microsurgery Unit, San Gerardo Hospital, Univ. of Milan Bicocca, Milan, Italy, Transplant Unit, St. Mary’s Hospital, London, UK, Microsearch Foundation, Sydney, Australia
  • Mots-clés : composite tissue allografts, human hand allografts, pathology, rejection
  • Page(s) : 235-8
  • Année de parution : 2005

The experience obtained from the human hand allografts (HHA) performed to date suggests that the skin is a priviledged target of allograft rejection in this setting. The aim of this study was to establish a pathological score for assessing the severity of HHA rejection. The pathological slides of 89 skin biopsies obtained from the allografted limbs of six HHA recipients from day 0 to 5 years post-graft were retrospectively examined. According to the severity of the pathological changes observed, the following grades of rejection are proposed: 0: no rejection, I: mild rejection, II: moderate rejection, III: severe rejection, IV: very severe rejection. This grading system can be used as a basis for monitoring allograft rejection and for assessing the effects of the immunosuppressive treatment aiming at reversing HHA rejection; it can also be used for monitoring rejection of other skin-containing CTA.