European Journal of Dermatology
MENUOlmsted syndrome with squamous cell carcinoma of extremities and adenocarcinoma of the lung: failure to detect loricrin gene mutation Volume 13, numéro 6, November - December 2003
Illustrations
Fumihide Ogawa, Masako Udono, Hiroyuki Murota, Kazuhiro Shimizu, Hidetoshi Takahashi, Akemi Ishida‐Yamamoto, Hajime Iizuka, Ichiro Katayama
Department of Dermatology, Nagasaki University School of Medicine, 1‐7‐1 Sakamoto, Nagasaki 852‐8501, Japan Department of Dermatology, Asahikawa Medical College, Midorigaoka‐Higashi 2‐1‐1‐1, Asahikawa 078‐8510, Japan
- Mots-clés : Olmsted syndrome, palmoplantar keratoderma, periorificial keratoderma, squamous cell carcinoma, adenocarcinoma, loricrin, osteolysis
- Page(s) : 524-8
- Année de parution : 2003
Olmsted syndrome is an uncommon disorder of keratinization that presents mutilating palmoplantar keratoderma, periorificial hyperkeratosis, leukokeratosis and alopecia. We report a new case of this rare syndrome diagnosed in 48‐year‐old woman who developed several squamous cell carcinomas of limbs and adenocarcinoma of the lung. She has been followed up for about 40 years and osteolytic changes of the fingers and toes accompanied the keratinizing disorder and squamous cell carcinoma. Loricrin gene mutation that is occasionally observed in loricrin keratoderma such as Vohwinkel‘s syndrome was not detected in the present case.