European Journal of Dermatology


Mild recessive dystrophic epidermolysis bullosa associated with two compound heterozygous COL7A1 mutations Volume 21, numéro 2, March-April 2011

Department of Dermatology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany, Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany, Department of Dermatology, Ruhr-University Bochum, Bochum, Germany, Center for Human Genetics Freiburg, Freiburg, Germany

Dystrophic epidermolysis bullosa is a group of inherited skin blistering disorders caused by mutations in the COL7A1 gene coding for type VII collagen. More than 500 different COL7A1 mutations have been detected in dystrophic epidermolysis bullosa to date. Clarification of genotype-phenotype correlations is of particular importance for the development of novel therapeutic approaches. Here we report a female patient with mild dystrophic epidermolysis bullosa harbouring two compound heterozygous COL7A1 mutations, namely the intronic splice site mutation c.3832-2A > G and the glycine substitution p.G1347W. Our data extend the current knowledge on genotype-phenotype correlations in dystrophic epidermolysis bullosa.