John Libbey Eurotext

European Journal of Dermatology

Merkel cell carcinoma: new insights into pathogenesis Article à paraître

Illustrations

  • Figure 1
Auteurs
1 HPV-UNIT, RIDAIT Dept,
Regina Elena National Cancer Institute,
Rome, Italy
2 Laboratory of Cutaneous Histopathology,
San Gallicano Dermatologic Institute,
Rome, Italy
3 Gynaecologic Oncology Dept,
Regina Elena National Cancer Institute,
Rome, Italy
4 Plastic Surgery Dept,
San Gallicano Dermatologic Institute,
Rome, Italy

The Merkel cell polyomavirus (MCPyV) has been shown to be clonally integrated into the genome of ca. 80% of human Merkel cell carcinoma (MCC) cases [1]. Indeed, MCC is associated with Large Tumour (LT)-antigen expression within the tumour and with mutations in the LT-coding gene. A variety of other circular dsDNA viruses can infect the skin, including a wide range of human papillomavirus (HPV) species [2].Epidemiological studies suggest a relationship between β-HPV and non-melanoma skin cancer in [...]