European Journal of Dermatology


Journal Club: Update on pyoderma gangrenosum Volume 33, numéro 5, September-October 2023

1 Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany
2 CIRI, Centre International de Recherche en Infectiologie, (Team Epidermal Immunity and Allergy); INSERM, U1111; Univ Lyon; Université de Lyon 1; École Normale Supérieure de Lyon; CNRS, UMR 5308, Lyon, France
3 Department of Dermatology, Hôpital Edouard Herriot, Lyon, France
4 Department of Dermatology, Centro Hospitalar Universitário de Santo António, Porto, Portugal
5 Department of Dermatology, Addenbrooke’s Hospital, Cambridge University Hospitals, Cambridge, United Kingdom
6 Department of Dermatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain
7 Department of Dermatology, Hospital Universitario Puerta de Hierro, Majadahonda, Spain
8 Department of Allergology and Immunology, Centre Hospitalier Lyon Sud, Pierre-Bénite, France

Pyoderma gangrenosum (PG) was first described in 1930 [1] by Brunsting et al., and its pathogenesis remains a mystery to this day. PG occurs at a rate of 0.6 per 100,000 individuals per year [2], classifying it as a rare disease. Clinically, PG presents as pustules, opaque vesicles, or inflammatory nodules, often emerging after minor injuries or surgical procedures and progressing into large ulcers. This phenomenon is referred to as pathergy phenomenon [3]. It predominantly affects the lower extremities, [...]