John Libbey Eurotext

European Journal of Dermatology

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Is the distribution of dermal neurofibromas in neurofibromatosis type 1 (NF1) related to the pattern of the skin surface temperature? Volume 11, numéro 6, November - December 2001

Auteurs
Abteilung Humangenetik, Universität Ulm, Albert-Einstein-Allee 11, D 89070 Ulm, Germany.
  • Page(s) : 521-5
  • Année de parution : 2001

The formation of numerous dermal neurofibromas is a hallmark of neurofibromatosis type 1 (NF1) [1-3]. These tumours differ in biology from the superficially visible diffuse plexiform neurofibromas: Plexiform neurofibromas are thought to be congenital lesions occurring relatively infrequently [1, 4]. NF1 has been shown to have tumour suppressor gene function. According to Knudson's "two hit model" a total loss of the NF1 product neurofibromin in [...]