John Libbey Eurotext

European Journal of Dermatology


Finasteride in the treatment of Japanese men with male pattern hair loss Volume 14, numéro 4, July-August 2004

Tokyo Women’s Medical University, School of Medicine, Department of Dermatology8‐1, Kawada‐cho, Shinjuku Tokyo, 162‐8666 Japan Kanto Medical Center NTT EC Kitahara Dermatology Clinic Shinjuku Minamiguchi Dermatology Skin Clinic Daikanyama NS Clinic Toda Dermatology Clinic Tokyo Medical University, Department of Dermatology Juntendo University School of Medicine, Department of Dermatology Yotsuya 3 chome Dermatology Banyu Pharmaceutical Co., Ltd.

Finasteride is a type 2 5α‐reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone, a key mediator of male pattern hair loss (androgenetic alopecia). The objective of this study was to identify the optimal dosage of finasteride and to evaluate its efficacy and safety in the treatment of Japanese men with male pattern hair loss. In this double‐ blind randomized study, 414 Japanese men with male pattern hair loss received finasteride 1 mg (n ∓ 139), finasteride 0.2 mg (n ∓ 137), or placebo (n ∓ 138) once daily for 48 weeks. Efficacy was evaluated by global photographic assessment, patient self‐assessment, and investigator assessment. All efficacy endpoints showed significant improvement with finasteride therapy by 12 weeks (p < 0.05 versus placebo). At 48 weeks, 58%, 54%, and 6% of men in the finasteride 1 mg, finasteride 0.2 mg, and placebo groups, respectively, had improved based on assessments of global photographs. All efficacy endpoints were numerically superior for the 1 mg dose over the 0.2 mg dose at 48 weeks. Finasteride treatment was generally well tolerated. Finasteride 1 mg\day slows hair loss and improves hair growth in Japanese men with male pattern hair loss.