John Libbey Eurotext

European Journal of Dermatology

Fatal natural killer cell lymphoma arising in a patient with a crop of Epstein-Barr virus-associated disorders Volume 15, issue 6, November-December 2005

  • Auteur(s) : Yukiko Nitta, Keiji Iwatsuki, Hiroshi Kimura, Seiji Kojima, Tsuneo Morishima, Kazuhide Tsuji, Takashi Oono , Department of Dermatology, National Hospital Organization Nagoya Medical Center, Nagoya 460-0001, Japan, Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho Okayama 700-8558, Japan Fax: (+81) 86 235 7283, Departments of Pediatrics, Nagoya University School of Medicine, Nagoya 466-8560, Japan, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan
  • Mots-clés : EB virus, hydroa vacciniforme, haemophagocytosis, nasal lymphoma, natural killer cell, mosquito bite
  • Page(s) : 503-6
  • Année de parution : 2005

Natural killer (NK) lymphoma in Asia is frequently associated with latent Epstein-Barr (EBV) infection. Unlike the adult cases, EBV-associated NK/T cell lymphomas in children are often preceded by various EBV-related disorders, including chronic active EBV infection (CAEBV), hypersensitivity to mosquito bites (HMB), virus-associated haemophagocytic syndrome (VAHS), and hydroa vacciniforme (HV)-like eruptions. Here, we report a 14-year-old Japanese girl who sequentially developed all the symptoms related to EBV-associated NK/T cell lymphoproliferative disorders in a 12-year clinical course. Our observations confirm the spectrum of EBV-associated cutaneous disorders and indicate the importance of long-term follow-up.

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