John Libbey Eurotext

European Journal of Dermatology


Eosinophilia and systemic symptoms with transient ageusia: a drug reaction caused by zonisamide Volume 28, numéro 4, July-August 2018


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Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan

Drug-induced taste disorders (DITDs) represent a side effect of drugs and usually occur without other symptoms. To date, no drug eruption has ever been reported in association with DITD. We report herein a case of zonisamide-induced drug reaction with eosinophilia and systemic symptoms (DRESS) associated with transient but severe ageusia.A 50-year-old man with epilepsy had been treated with sodium valproate, phenytoin, phenobarbital, and diazepam for six years. Three months after the additional administration [...]