John Libbey Eurotext

European Journal of Dermatology


Endometriosis in the setting of Muckle-Wells syndrome treated with an IL-1β antagonist Volume 27, numéro 4, July-August 2017


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Department of Dermatology,
University of Occupational and Environmental Health,
1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555,

Cryopyrin-associated autoinflammatory syndrome (CIAS) is characterized by a triad of rash, arthropathy, and central nervous system involvement [1]. Chronic infantile neurological cutaneous articular syndrome (CINCA), Muckle-Wells syndrome, and familial cold autoinflammatory syndrome have been shown to be allelic, caused by heterozygous mutations in the CIAS gene, NLPR3, on chromosome 1q44, which encodes a pyrin-like protein [2]. Interleukin (IL)-1 antagonists are emerging as an effective therapy [...]