John Libbey Eurotext

European Journal of Dermatology

Efficacy and local safety of a calcipotriol/ betamethasone dipropionate ointment in elderly patients with psoriasis vulgaris Volume 15, numéro 1, January-February 2005

Auteurs
Royal Liverpool and Broadgreen University Hospitals Trust, Liverpool L69 3BX, England Fax: +44 (0)151 282 6899., LEO Pharma A/S, Industriparken 55, DK-2750 Ballerup, Denmark
  • Mots-clés : betamethasone dipropionate, calcipotriol, geriatric, psoriasis therapy
  • Page(s) : 37-9
  • Année de parution : 2005

The proportion of elderly patients with psoriasis vulgaris is set to increase in the future due to an ageing population. This descriptive analysis assessed the efficacy and safety of a new ointment containing calcipotriol and betamethasone dipropionate (Daivobet ®/Dovobet ®) in a pooled analysis of patients aged 60 years and over. A total of 1534 patients, including 357 aged ≥ 60 years, with psoriasis vulgaris received the two-compound ointment once-daily in four randomised, double-blind, studies. After 4 weeks treatment the mean reduction in PASI was 67.8% in patients < 60 years compared with 72.6% in patients ≥ 60 years. “Controlled disease” (i.e. a global assessment of “absence of disease” or “very mild disease”), according to the investigators, was achieved by 52.1% of patients < 60 years and 58.2% of patients ≥ 60 years. Patients in both age groups reported a similar number of lesional/perilesional adverse drug reactions; 6.4% in patients < 60 years vs 5.0% in patients ≥ 60 years. Thus, the new two-compound ointment is effective and well-tolerated in the treatment of psoriasis vulgaris, regardless of age group.