Professor, Department of Dermatology, Federal University of São Paulo, SP, Brazil. Thesis advisor, Translational Medicine Post-Graduation Program, Federal University of São Paulo, São Paulo, Brazil
Director, Dona Libânia Dermatology center, Department of Health, Ceará, Brazil
Dermatologist, Federal University of Paraná, Paraná, Brazil
Professor; Department of Dermatology, Medical Sciences College, Minas Gerais, Brazil. Preceptor of the medical residency of the Santa Casa, Minas Gerais, Brazil
Associate professor, Department of Dermatology, FMB-Unesp, São Paulo Brazil
Background: Adapalene has been previously evaluated as a treatment for actinic keratosis (AK) and solar lentigines and shown to improve signs of photoaging. Objectives: To evaluate whether adapalene 0.3% gel is non-inferior to tretinoin 0.05% cream as treatment for photoaged skin. Materials & Methods: An investigator-blinded, parallel-group comparison study was conducted in Brazil. Subjects were randomised in a 1:1 ratio to receive, once daily, adapalene 0.3% gel or tretinoin 0.05% cream. Subjects were evaluated at Weeks 1, 4, 8, 12, 16, 20 and 24, based on clinical signs of cutaneous photoaging, histopathological and digital morphometric findings, as well as safety and tolerability. Results: A comparison of clinical efficacy showed that both treatments did not differ significantly regarding clinical evaluation of the following criteria: global cutaneous photoaging, periorbital wrinkles, ephelides/melanosis, forehead wrinkles, and AK. Conclusion: Adapalene 0.3% gel showed non-inferior efficacy to tretinoin 0.05% cream as treatment for photoaged skin, with a similar safety profile. Adapalene 0.3% gel may therefore be considered a safe and effective option for the treatment of mild or moderate photoaging.