John Libbey Eurotext

European Journal of Dermatology

Collagen-receptor signaling in health and disease Volume 11, numéro 6, November - December 2001

Illustrations

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  • Auteur(s) : W. F. VOGEL , Laboratory of Extracellular Matrix Signaling and Tumor Invasion, Georg-Speyer-Haus, Institute for Biomedical Research, affiliated with the Johann Wolfgang Goethe-University Frankfurt, 60596 Frankfurt am Main, Germany.
  • Page(s) : 506-14
  • Année de parution : 2001

The ability to synthesize extracellular matrix (ECM) was an essential stepping stone during the early evolution of multicellular life. Synthesis and degradation of ECM proteins are critical not only for proper embryonic and postnatal development but throughout adulthood. In turn, any aberrant communication between cells and their surrounding ECM can lead to a plethora of human diseases, for example, atherosclerosis, arthritis, renal or lung fibrosis, ...