European Journal of Dermatology
MENUCLA + T cells in cutaneous diseases Volume 14, numéro 1, January-February 2004
Illustrations
Almirall Prodesfarma, Research Center, Cardener, 68‐74, 08024 Barcelona (Spain)
The Cutaneous Lymphocyte‐associated Antigen (CLA) was originally described as a cell surface molecule preferentially found on T lymphocytes present in the skin. At the present time, a more complete and exciting picture is emerging thanks to the efforts of different research groups. The CLA antigen identifies a subset of memory effector T lymphocytes functionally involved in the pathogenesis of different T cell‐mediated cutaneous diseases. Research related to CLA + T cells is not only becoming a source of interesting data related to the pathological mechanisms of skin disorders, but also provides an innovative and selective approach to develop new treatments for T cell‐mediated diseases in dermatology.