JLE

European Journal of Dermatology

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CLA + T cells in cutaneous diseases Volume 14, numéro 1, January-February 2004

Auteur
Almirall Prodesfarma, Research Center, Cardener, 68‐74, 08024 Barcelona (Spain)
  • Mots-clés : CLA, homing, skin
  • Page(s) : 13-8
  • Année de parution : 2004

The Cutaneous Lymphocyte‐associated Antigen (CLA) was originally described as a cell surface molecule preferentially found on T lymphocytes present in the skin. At the present time, a more complete and exciting picture is emerging thanks to the efforts of different research groups. The CLA antigen identifies a subset of memory effector T lymphocytes functionally involved in the pathogenesis of different T cell‐mediated cutaneous diseases. Research related to CLA + T cells is not only becoming a source of interesting data related to the pathological mechanisms of skin disorders, but also provides an innovative and selective approach to develop new treatments for T cell‐mediated diseases in dermatology.