European Journal of Dermatology


Bullous mycosis fungoides with large cell transformation: a fatal outcome following brentuximab treatment Volume 33, numéro 5, September-October 2023


  • Figure 1.
1 Serviço de Dermatologia, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal
2 Clínica Universitária de Dermatologia, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
3 IMM João Lobo Antunes, Lisbon, Portugal
4 Unidade de Dermatologia, Fundação Champalimaud, Lisbon, Portugal

Mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma, can manifest in a variety of clinical and histological forms [1]. Bullous mycosis fungoides (BMF) is extremely rare and since first described in 1887, only 35 cases have been reported in the literature [2]. In this report, we present the case of a male patient with generalized BMF accompanied by large cell transformation (LCT), which ultimately resulted in a fatal outcome after brentuximab vedotin treatment.A 74-year-old phototype [...]