John Libbey Eurotext

European Journal of Dermatology


Azathioprine combination therapy for steroid-refractory hepatic immune system-related adverse events Volume 27, numéro 3, May-June 2017


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1 Department of Dermatology,
University of Tsukuba,
Tsukuba, Ibaraki, Japan
2 Department of Medical Oncology,
University of Tsukuba, Tsukuba, Ibaraki, Japan

Enhancement of anti-tumour immunity has led to substantial progress in the treatment of melanoma. Two types of immune checkpoint inhibitors, ipilimumab, targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), and pembrolizumab and nivolumab, targeting programmed cell death-1 (PD-1), are now available. Treatment with these agents can cause immune system-related adverse events (IRAEs) that manifest as pneumonitis, colitis, pancreatitis, hypothyroidism or hepatitis (i.e. hepatic IRAE) [1-3]. [...]