John Libbey Eurotext

European Journal of Dermatology


An outbreak of hand-foot-and-mouth disease mimicking chicken pox, with a frequent association of onychomadesis in Japan in 2009: A new phenotype caused by coxsackievirus A6 Volume 24, numéro 1, January-February 2014


  • Figure 1
1 Department of Dermatology,
Department of Pediatrics,
Oita Children Hospital, Katashima 83-7,
Oita 870-0943, Japan
2 Department of Biostatistics,
3 Department of Dermatology,
Oita University, Idaigaoka 1-1,
Hasama-machi, Yufu,
Oita 879-5593, Japan
4 Department of Dermatology,
Dokkyo Medical University Koshigaya Hospital,
Minamikoshigaya 2-1-50, Koshigaya,
Saitama 343-8555, Japan

Hand-foot-and-mouth disease (HFMD) is primarily caused by coxsackievirus (CV) A16 and enterovirus 71 [1], whereas sporadic outbreaks have been caused by other viruses [2]. CVA6 is known to be a major pathogen of herpangina [3] and an outbreak of CVA6-associated HFMD followed by onychomadesis was reported in Finland in 2008 [4].We experienced an outbreak of HFMD with a new phenotype (N-HFMD; 133 patients; 52.4%, 79 males and 54 females) mimicking chicken pox and an outbreak of the common type (C-HFMD; [...]