John Libbey Eurotext

European Journal of Dermatology

Alefacept-induced decreases in circulating blood lymphocyte counts correlate with clinical response in patients with chronic plaque psoriasis Volume 13, numéro 2, March - April 2003


Ouvrir l'onglet

Psoriasis is an inflammatory skin disease characterized by keratinocyte hyperproliferation in the epidermis and recruitment of inflammatory cells in the dermis [1]. The deleterious role of T-cell - mediated immunity in the pathogenesis of psoriasis has been suspected on the basis of in situ studies showing that psoriatic lesions are infiltrated by type 1 helper T cells (CD4+) and type 1 cytotoxic T cells...