John Libbey Eurotext

European Journal of Dermatology


Alefacept-induced decreases in circulating blood lymphocyte counts correlate with clinical response in patients with chronic plaque psoriasis Volume 13, numéro 2, March - April 2003

Hôpital L'Archet II, 15 Rue de Saint Antoine de Ginestiere, BP 079, Nice, France
  • Page(s) : 117-23
  • Année de parution : 2003

Psoriasis is an inflammatory skin disease characterized by keratinocyte hyperproliferation in the epidermis and recruitment of inflammatory cells in the dermis [1]. The deleterious role of T-cell - mediated immunity in the pathogenesis of psoriasis has been suspected on the basis of in situ studies showing that psoriatic lesions are infiltrated by type 1 helper T cells (CD4+) and type 1 cytotoxic T cells [...]