John Libbey Eurotext

European Journal of Dermatology


Accelerated features of senescence in cultured type 2 diabetic skin fibroblasts Volume 27, numéro 4, July-August 2017


  • Figure 1
1 Laboratory of Molecular and Cell Biology
2 Laboratory of Vascular Pathology,
Istituto Dermopatico dell’Immacolata-IRCCS-FLMM
3 Laboratory of Cutaneous Physiopathology and Integrated Centre of Metabolomic Research,
San Gallicano Dermatologic Institute-IRCCS, Rome, Italy

Type 2 (non-insulin-dependent) diabetes mellitus (T2D) is a metabolic disease which causes chronic hyperglycaemia, biochemical and cellular disorders, and organ complications [1].It predisposes to lower extremity ulcerations and modifies the healing process, leading to chronic wounds [1]. High-glucose conditions cause oxidative stress in diabetes, which, in turn, induces premature senescence [2]. Senescent cells display several changes, such as growth arrest, alterations in gene expression, and a [...]