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European Journal of Dermatology

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A novel WRN mutation identified in a patient with Werner syndrome and acute generalized exanthematous pustulosis Volume 28, numéro 4, July-August 2018

Illustrations

  • Figure 1
Auteurs
1 Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
2 Department of Dermatology, Yamaguchi University Graduate School of Medicine, Ube, Japan

Werner syndrome (WS; OMIM 277700) is a group of hereditary progeria conditions with an autosomal recessive inheritance pattern, caused by mutations in the WRN gene [1]. Characteristic symptoms of WS are ulceration of the skin, atrophic and sclerotic skin, atherosclerosis, premature greying and loss of hair, cataracts, and a bird-like face [1]. Acute generalized exanthematous pustulosis (AGEP) is a drug-induced exanthema characterized by acute onset with numerous sterile pustules and high fever [2]. [...]