European Journal of Dermatology
MENUA novel WRN mutation identified in a patient with Werner syndrome and acute generalized exanthematous pustulosis Volume 28, numéro 4, July-August 2018
Illustrations
1 Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
2 Department of Dermatology, Yamaguchi University Graduate School of Medicine, Ube, Japan
- DOI : 10.1684/ejd.2018.3354
- Page(s) : 553-4
- Année de parution : 2018
Werner syndrome (WS; OMIM 277700) is a group of hereditary progeria conditions with an autosomal recessive inheritance pattern, caused by mutations in the WRN gene [1]. Characteristic symptoms of WS are ulceration of the skin, atrophic and sclerotic skin, atherosclerosis, premature greying and loss of hair, cataracts, and a bird-like face [1]. Acute generalized exanthematous pustulosis (AGEP) is a drug-induced exanthema characterized by acute onset with numerous sterile pustules and high fever [2]. [...]