European Journal of Dermatology


A case of ecthyma during therapy with an epidermal growth factor receptor inhibitor Volume 24, numéro 4, Juillet-Août


  • Figure 1
1 Department of Dermatology,
2 Department of Surgery, Odawara Municipal Hospital, Kuno 46, Odawara-shi, Kanagawa-ken, Japan

A 65-year-old man with a 3-year history of unresectable colon cancer was switched to FOLFIRI (5-fluorouracil, levofolinate calcium, irinotecan) and panitumumab, after the failure of FOLFIRI and bevacizumab, in February 2013. After the fourth dose of panitumumab, painful eruptions rapidly developed (figures 1A-C). An autoimmune bullous disease, subcorneal pustular dermatosis and impetigo contagiosa were suspected. However, no autoantibodies against bullous pemphigoid-180, desmoglein 1,or desmoglein [...]