John Libbey Eurotext

European Cytokine Network


Treatment failure with antagonists of TNF-α: mechanisms and implications for the care of patients Volume 21, numéro 4, December 2010

Inserm U996, Service de microbiologie-Immunologie Biologique, Hôpital Antoine-Béclère, Université Paris-Sud, Clamart, France

The use of TNF-α antagonists has substantially improved the care of many patients with inflammatory and autoimmune diseases. However, approximately one third of such patients fail to respond well to treatment, regardless of the antagonist used or of the underlying disease. The mechanisms underlying these failures are analyzed in this review, and proposals made concerning how best to adapt therapeutic decisions in these instances.