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European Cytokine Network

Thrombopoietin and its receptor. Volume 9, numéro 3, September 1998

INSERM U. 362, Institut Gustave-Roussy, 39, rue Camille-Desmoulins, 94805 Villejuif, France.
  • Mots-clés : thrombopoietin, TPO.
  • Page(s) : 221-31
  • Année de parution : 1998

THE Mpl RECEPTOR Structure and general functions Discovery. A portion of the thrombopoietin receptor, the c-mpl gene, was initially discovered fused to viral sequences encoding the envelope protein of the mutant murine myeloproliferative leukemia virus (MPLV). The ability of the oncogene v-mpl to transform a variety of hematopoietic progenitor cells [1-3] and its homology to members of the cytokine receptor superfamily [...]