John Libbey Eurotext

European Cytokine Network

Three novel mammalian toll-like receptors: gene structure, expression, and evolution Volume 11, numéro 3, September 2000


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INTRODUCTION The prototypic Toll protein of Drosophila melanogaster is a plasma membrane receptor characterized by a single transmembrane domain and a series of leucine-rich ectodomain repeats. It has been shown to fulfill both developmental and immunological functions, triggering dorsoventral patterning of the embryo [1, 2] and defending against fungal infections in adult life [3]. Similarly, the Toll ortholog 18-wheeler is required...