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European Cytokine Network

Three novel mammalian toll-like receptors: gene structure, expression, and evolution Volume 11, numéro 3, September 2000

Scripps Research Institute, 10550 N. Torrey Pines Road, IMM-31, R204, La Jolla, CA 92037, USA.
  • Page(s) : 362-71
  • Année de parution : 2000

INTRODUCTION The prototypic Toll protein of Drosophila melanogaster is a plasma membrane receptor characterized by a single transmembrane domain and a series of leucine-rich ectodomain repeats. It has been shown to fulfill both developmental and immunological functions, triggering dorsoventral patterning of the embryo [1, 2] and defending against fungal infections in adult life [3]. Similarly, the Toll ortholog 18-wheeler is required [...]