John Libbey Eurotext

European Cytokine Network

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The interleukin-6 G(-174)C polymorphism and the ex vivo interleukin-6 response to endotoxin in severely injured blunt trauma patients Volume 13, numéro 1, March 2002

Auteurs
Department of Anesthesia, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD Amsterdam, The Netherlands. Tel
  • Page(s) : 72-7
  • Année de parution : 2002

INTRODUCTION Major surgery and severe blunt trauma induce a generalized inflammatory reaction. Subsequently, sepsis and multiple organ failure develop in some patients, but not in others. The inflammatory response involves a complex pattern of humoral and cellular responses and the expression of related factors is thought to be governed by genetic variabilities [1-4]. Cytokines are integral components of the host immune response to trauma [...]