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Synergism between interleukin-6 and interleukin-1beta in hypothalamic serotonin release: a reverse in vivo microdialysis study in F344 rats. Volume 10, numéro 1, March 1999

Auteurs
Laboratoire de Neuropharmacologie, Faculté de Pharmacie-Université Paris-Sud, 92296 Chatenay-Malabry Cedex, France.
  • Page(s) : 57-64
  • Année de parution : 1999

INTRODUCTION Interleukin-6 (IL-6) is an inflammatory cytokine produced by practically every injured tissue and its expression is readily induced by infections, endotoxins, and a variety of other cytokines, including tumor necrosis factor-alpha (TNF-alpha), interferon (IFN)-gamma and interleukin-1 (IL-1). The two major cellular sources of brain IL-6 and IL-1 are microglial cells (predominantly) and neurons. Neuronal IL-6 and [...]