John Libbey Eurotext

European Cytokine Network


Subunit structure of the high and low affinity human interleukin-15 receptors. Volume 11, numéro 2, June 2000

Groupe de Recherche Cytokines/Récepteurs et Transduction, Unité INSERM 463, Institut de Biologie, 9, Quai Moncousu, 44035 Nantes Cedex 01, France, and Centre Hospitalier Universitaire, Nantes, France
  • Page(s) : 207-15
  • Année de parution : 2000

INTRODUCTION IL-15 is a cytokine discovered through its ability to stimulate the proliferation of the IL-2-dependent CTLL-2 murine T cell line [1, 2]. IL-15 does not share significant sequence homology with IL-2 but both molecules belong to the structural sub-family of cytokines made up of a bundle of four short alpha helices organized in an up-up-down-down configuration [3-5]. Unlike IL-2, whose mRNA expression is restricted to activated [...]