John Libbey Eurotext

European Cytokine Network


Seminal plasma adipokines: involvement in human reproductive functions Volume 28, numéro 4, October-November-December 2017


1 Assistance Publique des Hôpitaux de Paris, Hôpital Tenon, Service de Biologie de la Reproduction, Université Pierre et Marie Curie Paris 6, Paris, France
2 Sorbonne Universités, UPMC Université Paris 06, INSERM UMRS_938, Centre de Recherche Saint-Antoine, IHU ICAN, Paris, France
3 Assistance Publique des Hôpitaux de Paris, Hôpital Tenon, UF Biomarqueurs Inflammatoires et Métaboliques, Service de Biochimie et Hormonologie, Paris, France
4 INRA, UMR85, Physiologie de la Reproduction et des Comportements, Nouzilly, France
5 Assistance Publique des Hôpitaux de Paris, Hôpital Saint-Antoine, Service d’Endocrinologie, Paris, France
* Correspondence: Y Elfassy
1 These authors contributed equally to this work
  • Mots-clés : adipokines, semen, infertility, metabolic disorders
  • DOI : 10.1684/ecn.2018.0403
  • Page(s) : 141-50
  • Année de parution : 2017

Infertility, which increased worldwide over the past few decades, has recently been linked to obesity prevalence. Adipokines, produced by adipose tissue, could be the link between obesity and infertility. The association between circulating adipokines and female infertility has been extensively studied in the last ten years. However, the male aspect has been less investigated, although some adipokines are present in seminal plasma. We have attempted to analyze published studies that measured seminal plasma adipokines and their relationships with semen parameters. Apart from leptin, other seminal adipokines have rarely been studied. Indeed, leptin seems to have a differential role depending on its concentration in the seminal plasma. Thus, it could have a beneficial effect at lower concentrations but a deleterious effect at higher seminal levels. Although some studies are currently available, the roles of leptin and other adipokines in seminal plasma on sperm parameters and their consequences on male fertility remain to be clarified.