John Libbey Eurotext

European Cytokine Network

Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion Volume 13, numéro 2, June 2002


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INTRODUCTION The pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6 and IL-8 are important mediators in immune regulation and are produced during immune and host defence responses. Tumor necrosis factor (TNF-alpha) is a pleiotropic cytokine, produced primarily by macrophages in response to bacterial and viral pathogens. The pro-inflammatory functions of TNF-alpha include up-regulation of endothelial cells adhesion molecule expression...