- Auteur(s) : M. G. Smirnova, S. L. Kiselev, N. V. Gnuchev, J. P. Birchall, J. P. Pearson
, Department of Physiological Sciences, University of Newcastle, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
- Page(s) : 161-72
- Année de parution : 2002
The pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6 and IL-8 are
important mediators in immune regulation and are produced during immune
and host defence responses.
Tumor necrosis factor (TNF-alpha) is a pleiotropic cytokine, produced
primarily by macrophages in response to bacterial and viral pathogens.
The pro-inflammatory functions of TNF-alpha include up-regulation of endothelial
cells adhesion molecule expression...