John Libbey Eurotext

European Cytokine Network


Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion Volume 13, numéro 2, June 2002

Department of Physiological Sciences, University of Newcastle, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
  • Page(s) : 161-72
  • Année de parution : 2002

INTRODUCTION The pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6 and IL-8 are important mediators in immune regulation and are produced during immune and host defence responses. Tumor necrosis factor (TNF-alpha) is a pleiotropic cytokine, produced primarily by macrophages in response to bacterial and viral pathogens. The pro-inflammatory functions of TNF-alpha include up-regulation of endothelial cells adhesion molecule expression, [...]